Thank you for your purchase of breaking free, the updated 2026 edition!

Below is the complete Harvard reference list, which mirrors the reference page in the back of your book and the superscript numbers throughout the book.

Introduction

  1. Geraghty, K.J. (2021) ‘The wrong illness: a qualitative study of the experiences of people with myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS) with the UK health care system’, Qualitative Health Research, 31(2), pp. 315–328. doi: 10.1177/1049732320969395.

  2. Rothney, J. (2022) Breaking Free: A Guide to Recovering from Chronic Fatigue Syndrome and Long COVID Symptoms. Audiobook narrated by Jan Rothney. Arkbound Foundation. Audible. Available at:https://www.audible.co.uk/pd/Breaking-Free-Audiobook/B0C5JYJ977

  3. National Institute for Health and Care Excellence (NICE) (2021) Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management. NICE guideline NG206. London: NICE. Available at:https://www.nice.org.uk/guidance/ng206

  4. Action for M.E. (2025) Action for M.E.

  5. Vahratian, A., Lin, J.S., Bertolli, J. and Unger, E.R. (2023) ‘Myalgic encephalomyelitis/chronic fatigue syndrome in adults: United States, 2021–2022’, NCHS Data Brief, no. 488. Hyattsville, MD: National Center for Health Statistics. Available at:https://www.cdc.gov/nchs/products/databriefs/db488.htm

  6. Office for National Statistics (ONS) (2024) Self-reported coronavirus (COVID-19) infections and associated symptoms, England and Scotland: November 2023 to March 2024. Available at:https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/articles/sociatedsymptomsenglandandscotland/november2023tomarch2024

  7. Davis, H.E., Assaf, G.S., McCorkell, L., Wei, H., Low, R.J., Re’em, Y., Redfield, S., Austin, J.P. and Akrami, A. (2021) ‘Characterizing long COVID in an international cohort: 7 months of symptoms and their impact’, EClinicalMedicine, 38, 101019. doi: 10.1016/j.eclinm.2021.101019.

  8. Bartsch, S.M., Chin, K.L., Strych, U., John, D.C., Shah, T.D., Bottazzi, M.E., O’Shea, K.J., Robertson, M., Weatherwax, C., Heneghan, J., Martinez, M.F., Ciciriello, A., Kulkarni, S., Velmurugan, K., Dibbs, A., Scannell, S.A., Shen, Y., Nash, D., Hotez, P.J. and Lee, B.Y. (2025) ‘The current and future burden of long COVID in the United States’, The Journal of Infectious Diseases, 231(6), pp. 1581–1590. Available at:https://doi.org/10.1093/infdis/jiaf030

  9. Wu, Z. and McGoogan, J.M. (2020) ‘Characteristics of and important lessons from the coronavirus disease 2019 (COVID-19) outbreak in China’, JAMA, 323(13), pp. 1239–1242. doi: 10.1001/jama.2020.2648.

  10. Wong, T.L. and Weitzer, D.J. (2021) ‘Long COVID and myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS): a systematic review and comparison of clinical presentation and symptomatology’, Medicina, 57(418), pp. 1–14. doi: 10.3390/medicina57050418.

  11. Kamau-Mitchell, C. (2021) ‘GPs need awareness about post-COVID ME/CFS’, BMJ, 374, n1995. doi: 10.1136/bmj.n1995.

  12. World Health Organization (WHO) (2024) Post COVID-19 condition (Long COVID). Available at:https://www.who.int/europe/news-room/fact-sheets/item/post-covid-19-condition#:~:text=Definition,months%20with%20no%20other%20explanatation

  13. Soriano, J.B., Murthy, S., Marshall, J.C., Relan, P. and Diaz, J.V. (2022) ‘A clinical case definition of post-COVID-19 condition by a Delphi consensus’, The Lancet Infectious Diseases, 22(4), pp. e102–e107. doi: 10.1016/S1473-3099(21)00703-9.

  14. Nicholson, T. (2022) New study identifies 12 key outcomes to assess Long COVID treatments. Institute of Psychiatry, Psychology and Neuroscience, King’s College London. Available at:https://www.kcl.ac.uk/news/new-study-identifies-12-key-outcomes-to-assess-long-covid-treatments

  15. Costeira, R. and Lee, K. (2020) Post-menopausal women at higher risk of developing severe COVID-19. medRxiv. Available at:https://www.kcl.ac.uk/news/post-menopausal-women-higher-risk-developing-severe-covid-19

  16. Selvakumar, J., Havdal, L.B., Brodwall, E.M., Sommen, S., Berven, L.L., Stiansen-Sonerud, T., Cvejic, E. and Wyller, V.B.B. (2025) ‘Risk factors for fatigue severity in the post-COVID-19 condition: a prospective controlled cohort study of nonhospitalised adolescents and young adults’, Brain, Behavior, & Immunity – Health, 44. doi: 10.1016/j.bbih.2025.100967.

  17. Brodwall, E.M., Selvakumar, J., Havdal, L.B., Sommen, S., Berven, L.L., Cvejic, E., Wyller, V.B.B. and Pedersen, M. (2025) ‘Predictors of fatigue progression in long COVID among young people’, Brain, Behavior, & Immunity – Health, 45. doi: 10.1016/j.bbih.2025.100982.

  18. Naviaux, R.K. (2020) ‘Perspective: cell danger response biology—the new science that connects environmental health with mitochondria and the rising tide of chronic illness’, Mitochondrion, 51, pp. 40–45. doi: 10.1016/j.mito.2019.12.002.

  19. (1) Tamburro, G. et al. (2020) ‘Modulation of brain functional connectivity and efficiency during an endurance cycling task: a source-level EEG and graph theory approach’, Frontiers in Human Neuroscience, 14(243), pp. 1–10. doi: 10.3389/fnhum.2020.00243.
    (2) Boksem, M.A.S. et al. (2008) ‘Mental fatigue: costs and benefits’, Brain Research Reviews, 59, pp. 125–139. doi: 10.1016/j.brainresrev.2008.07.001.

    (3) Krupnik, V. (2024) ‘I like therefore I can, and I can therefore I like: the role of self-efficacy and affect in active inference of allostasis’, Frontiers in Neural Circuits, 14, p. 243. doi: 10.3389/fncir.2024.1283372.

  20. Garner, P. (2021) Long-haul COVID brings long road to recovery. WebMD. Available at:https://www.webmd.com/lung/news/20210630/long-haul-covid-brings-long-road-to-recovery

  21. Mineo, L. (2017) Good genes are nice, but joy is better, The Harvard Gazette, 11 April. Available at:https://news.harvard.edu/gazette/story/2017/04/over-nearly-80-years-harvard-study-has-been-showing-how-to-live-a-healthy-and-happy-life/

  22. Porges, S.W. (2001) ‘The polyvagal theory: phylogenetic substrates of a social nervous system’, International Journal of Psychophysiology, 42(2), pp. 123–146. Elsevier. doi: 10.1016/S0167-8760(01)00162-4.

    Chapter 1

  23. (1) Leibowitz, K.A., Hardebeck, E.J., Goyer, J.P. and Crum, A.J. (2018) ‘Physician assurance reduces patient symptoms in US adults: an experimental study’, Journal of General Internal Medicine, 33(12), pp. 2051–2052. doi: 10.1007/s11606-018-4618-0.

    (2) Yeager, D.S., Trzesniewski, K.H., Spitzer, B.J., Powers, J., Johnson, R. and Dweck, C.S. (2014) ‘The far-reaching effects of believing people can change: implicit theories of personality shape stress, health, and achievement during adolescence’, Journal of Personality and Social Psychology, 106(6), pp. 867–881. doi: 10.1037/a0036335.

    (3) Rakel, D., Barrett, B., Zhang, Z., Hoeft, T., Chewning, B., Marchand, L. and Scheder, J. (2011) ‘Perception of empathy in the therapeutic encounter: effects on the common cold’, Patient Education and Counseling, 85(3), pp. 390–397. doi: 10.1016/j.pec.2011.01.009.

    (4) Leibowitz, K.A., Hardebeck, E.J., Goyer, J.P. and Crum, A.J. (2019) ‘The role of patient beliefs in open-label placebo effects’, Health Psychology, 38(7), pp. 613–622. doi: 10.1037;

    (5) Howe, L.C., Goyer, J.P. and Crum, A.J. (2017) ‘Harnessing the placebo effect: exploring the influence of physician characteristics on placebo response’, Health Psychology, 36(11), pp. 1074–1082. doi: 10.1037/hea0000499.

  24. (1) Carvalho, C., Caetano, J.M., Cunha, L., Rebouta, P., Kaptchuk, T.J. and Kirsch, I. (2016) ‘Open-label placebo treatment in chronic low back pain: a randomized controlled trial’, Pain, 157(12), pp. 2766–2772. doi: 10.1097/j.pain.0000000000000700.

    (2) Carvalho, C., Pais, M., Cunha, L., Rebouta, P., Kaptchuk, T.J. and Kirsch, I. (2020) ‘Open-label placebo for chronic low back pain: a 5-year follow-up’, Pain, 162(5), pp. 1521–1527. doi: 10.1097/j.pain.0000000000001816.

  25. Kaptchuk, T.J. and Miller, F.G. (2018) ‘Open-label placebo: can honestly prescribed placebos evoke meaningful therapeutic benefits?’, BMJ, 363, k3889. doi: 10.1136/bmj.k3889.

  26. Schaefer, M., Sahin, T. and Berstecher, B. (2018) ‘Why do open-label placebos work? A randomized controlled trial of an open-label placebo induction with and without extended information about the placebo effect in allergic rhinitis’, PLoS One, 13(3), e0192758. doi: 10.1371/journal.pone.0192758.

  27. Auer, C.J., Laferton, J.A., Shedden-Mora, M.C., Salzmann, S., Moosdorf, R. and Rief, W. (2017) ‘Optimizing preoperative expectations leads to a shorter length of hospital stay in CABG patients: further results of the randomized controlled PSY-HEART trial’, Journal of Psychosomatic Research, 97, pp. 82–89. doi: 10.1016/j.jpsychores.2017.03.016.

  28. Rief, W., Shedden-Mora, M.C., Laferton, J.A., Auer, C., Petrie, K.J., Salzmann, S., Schedlowski, M. and Moosdorf, R. (2017) ‘Preoperative optimization of patient expectations improves long-term outcome in heart surgery patients: results of the randomized controlled PSY-HEART trial’, BMC Medicine, 15(1), 4. doi: 10.1186/s12916-016-0767-3.

  29. Miller, A., Symington, F., Garner, P. and Pedersen, M. (2025) ‘Patients with severe ME/CFS need hope and expert multidisciplinary care’, BMJ, 389, r977. doi: 10.1136/bmj.r977.

  30. Leibowitz, K.A., Hardebeck, E.J., Goyer, J.P. and Crum, A.J. (2018) ‘Physician assurance reduces patient symptoms in US adults: an experimental study’, Journal of General Internal Medicine, 33(12), pp. 2051–2052. doi: 10.1007/s11606-018-4618-0.

  31. Scott, D.J., Stohler, C.S., Egnatuk, C.M., Wang, H., Koeppe, R.A. and Zubieta, J.K. (2008) ‘Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses’, Archives of General Psychiatry, 65(2), pp. 220–231.

  32. Enck, P., Benedetti, F. and Schedlowski, M. (2008) ‘New insights into the placebo and nocebo responses’, Neuron, 59(2), pp. 195–206. doi: 10.1016/j.neuron.2008.06.030.

  33. Lipton, B. (2015) Biology of Belief. California: Elite Books.

  34. (1) Hamilton, D. (2008) How Your Mind Can Heal Your Body. London: Hay House Inc.

    (2) Hamilton, D. (2008) It’s the Thought that Counts. London: Hay House Inc.

  35. Robson, D. (2022) The Expectation Effect. Edinburgh: Canongate Books.

  36. Alme, T.N., Andreasson, A., Asprusten, T.T., Bakken, A.K., Beadsworth, M.B. et al. (2023) ‘Chronic fatigue syndromes: real illnesses that people can recover from’, Scandinavian Journal of Primary Health Care, 41(4), pp. 372–376. doi: 10.1080/02813432.2023.2235609.

  37. Seligman, M.E.P. and Groves, D.P. (1970) ‘Nontransient learned helplessness’, Psychonomic Science, 19, pp. 191–192. doi: 10.3758/BF03335546.

  38. National Institute for Health and Care Excellence (NICE) (2021) Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management. NICE guideline NG206. Available at: https://www.nice.org.uk/guidance/ng206/resources/myalgic-encephalomyelitis-or-encephalopathychronic-fatigue-syndrome-diagnosis-and-management-pdf-66143718094021

  39. ScienceDaily (2025) Breakthrough blood test finally confirms Chronic Fatigue Syndrome, ScienceDaily, 3 November. Available at: https://www.sciencedaily.com/releases/2025/11/251102205021.htm

  40. National Institute for Health and Care Excellence (NICE) (2021) Myalgic encephalomyelitis (or encephalopathy)/chronic fatigue syndrome: diagnosis and management (NG206). Available at: https://www.nice.org.uk/guidance/ng206/resources/myalgic-encephalomyelitis-or-encephalopathychronic-fatigue-syndrome-diagnosis-and-management-pdf-66143718094021

  41. Chester, R., Khondoker, M., Shepstone, L., Lewis, J.S. and Jerosch-Herold, C. (2019) ‘Self-efficacy and risk of persistent shoulder pain: results of a Classification and Regression Tree (CART) analysis’, British Journal of Sports Medicine, 53(13), pp. 825–834. doi: 10.1136/bjsports-2018-099450.

  42. Yeager, D.S., Johnson, R., Spitzer, B.J., Trzesniewski, K.H., Powers, J. and Dweck, C.S. (2014) ‘The far-reaching effects of believing people can change: implicit theories of personality shape stress, health, and achievement during adolescence’, Journal of Personality and Social Psychology, 106(6), pp. 867–884. doi: 10.1037/a0036335.

  43. Nerli, T.F., Selvakumar, J., Cvejic, E. et al. (2024) ‘Brief outpatient rehabilitation program for post–COVID-19 condition: a randomized clinical trial’, JAMA Network Open, 7(12), e2450744. doi: 10.1001/jamanetworkopen.2024.50744.

  44. Robson, D. (2022) The Expectation Effect. Edinburgh: Canongate Books.

  45. Hanlon, M. (2013) ‘Scientists under siege’, The Sunday Times, 5 May, pp. 12–19.

    Chapter 2

  46. Buczynski, R. and Porges, S. (2014) Transcript of: How Polyvagal Theory Expands Our Healing Paradigm. Available at:https://www.nicabm.com

  47. Myhill, S. (2017) It’s Mitochondria not Hypochondria. London: Hammersmith Health Books.

  48. Naviaux, R.K. (2014) ‘Metabolic features of the cell danger response’, Mitochondrion, 16, pp. 7–17. doi: 10.1016/j.mito.2013.08.006.

  49. Naviaux, R.K. (2018) ‘Metabolic features of the cell danger response’, Mitochondrion, 46, pp. 1–30. doi: 10.1016/j.mito.2018.02.003.

  50. (1) Cole, S.W. (2019) ‘The conserved transcriptional response to adversity’, Current Opinion in Behavioral Sciences, 28, pp. 31–37. doi: 10.1016/j.cobeha.2019.01.008.

    (2) Kraynak, T.E. et al. (2018) ‘Sympathetic nervous activity promotes proinflammatory gene transcription and cytokine production via beta-adrenergic receptor actions; parasympathetic activity has the opposite effect’, Neuroscience & Biobehavioral Reviews, 94, pp. 76–92.

  51. Dantzer, R. (2018) ‘Neuroimmune interactions: from the brain to the immune system and vice versa’, Physiological Reviews, 98(1), pp. 477–504. doi: 10.1152/physrev.00039.2016.

  52. (1) Nakatomi, Y., Mizuno, K., Ishii, A., Wada, Y., Tanaka, M., Tazawa, S., Onoe, K., Fukuda, S., Kawabe, J., Takahashi, K., Kataoka, Y., Shiomi, S., Yamaguti, K., Inaba, M., Kuratsune, H. and Watanabe, Y. (2014) ‘Neuroinflammation in patients with chronic fatigue syndrome/myalgic encephalomyelitis: an ¹¹C-(R)-PK11195 PET study’, Journal of Nuclear Medicine, 55(6), pp. 945–950. doi: 10.2967/jnumed.113.131045.

    (2) Fluge, Ø., Tronstad, K.J. and Mella, O. (2021) ‘Pathomechanisms and possible interventions in myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS)’, The Journal of Clinical Investigation, 131(14). doi: 10.1172/JCI150377.

  53. Lee, J.S., Sato, W. and Son, C.G. (2024) ‘Brain-regional characteristics and neuroinflammation in ME/CFS patients from neuroimaging: a systematic review and meta-analysis’, Autoimmunity Reviews, 23(2). doi: 10.1016/j.autrev.2023.103484.

  54. Raijmakers, R., Roerink, M., Keijmel, S., Joosten, L., Netea, M., van der Meer, J., Knoop, H., Klein, H., Bleeker-Rovers, C. and Doorduin, J. (2021) ‘No signs of neuroinflammation in women with chronic fatigue syndrome or Q fever fatigue syndrome using the TSPO ligand [11C]-PK11195’, Neurology: Neuroimmunology & Neuroinflammation, 9(1), pp. 1–10. doi: 10.1212/NXI.0000000000001113.

  55. Naviaux, R.K. (2020) ‘Perspective: cell danger response biology—the new science that connects environmental health with mitochondria and the rising tide of chronic illness’, Mitochondrion, 51(3), pp. 40–45. doi: 10.1016/j.mito.2019.12.005.

  56. Hunt, B.J., Kuehn, R., Fox, T., Carson, A., Scandrett, K., Davey Smith, G. and Garner, P. (2024) ‘Challenging the current hypothesis that thrombosis is responsible for the post-COVID-19 condition’, Research and Practice in Thrombosis and Haemostasis, 8(4), p. 102442. doi: 10.1016/j.rpth.2024.102442.

  57. Peluso, M.J. et al. (2025) An exploratory, randomized, double-blind placebo-controlled study to assess the safety of an anti-SARS-CoV-2 monoclonal antibody and response to treatment in individuals with Long COVID (outSMART-LC). ClinicalTrials.gov Identifier: NCT05877508.

  58. Naviaux, R.K. et al. (2016) Metabolic features of chronic fatigue syndrome: Q&A version, Proceedings of the National Academy of Sciences (PNAS), 9 September. Available at:https://naviauxlab.ucsd.edu/wp-content/uploads/2016/09/Metabolomics-QA-for-CFS-v12.pdf

  59. Lammi, V., Nakanishi, T., Jones, S.E. et al. (2025) ‘Genome-wide association study of long COVID’, Nature Genetics, 57, pp. 1402–1417. doi: 10.1038/s41588-025-02100-w.

  60. Oxford BioDynamics (2025) Breakthrough blood test finally confirms Chronic Fatigue Syndrome, ScienceDaily, 3 November. Available at:https://www.sciencedaily.com/releases/2025/11/251102205021.htm

  61. Picard, M., McManus, M.J., Gray, J.D., Nasca, C., Moffat, C., Kopinski, P.K., Seifert, E.L., McEwen, B.S. and Wallace, D.C. (2015) ‘Mitochondrial functions modulate neuroendocrine, metabolic, inflammatory, and transcriptional responses to acute psychological stress’, Proceedings of the National Academy of Sciences, 112(48), pp. E6614–E6623. doi: 10.1073/pnas.1515733112.

  62. Kraynak, T.E. et al. (2018) ‘Sympathetic nervous activity promotes proinflammatory gene transcription and cytokine production via beta-adrenergic receptor actions; parasympathetic activity has the opposite effect’, Neuroscience & Biobehavioral Reviews, 94, pp. 76–92; Cole, S.W. (2019) ‘The conserved transcriptional response to adversity’, Current Opinion in Behavioral Sciences, 28, pp. 31–37.

  63. COFFI (2025) Response to DecodeME preprint. Collaborative on Fatigue Following Infection (COFFI). Available at:https://www.coffi-collaborative.com/post/response-to-decodeme-preprint

  64. Alme, T.N., Andreasson, A., Asprusten, T.T., Bakken, A.K., Beadsworth, M.B. and Wyller, V.B.B. (2023) ‘Chronic fatigue syndromes: real illnesses that people can recover from’, Scandinavian Journal of Primary Health Care, 41(4), pp. 372–376. doi: 10.1080/02813432.2023.2235609.

  65. COFFI (2020) The Collaborative on Fatigue and Related Symptoms Following Infection (COFFI).

  66. Naviaux, R.K., Naviaux, J.C., Li, K., Bright, A.T., Alaynick, W.A., Wang, L., Baxter, A., Nathan, N., Anderson, W. and Gordon, E. (2016) ‘Metabolic features of chronic fatigue syndrome’, Proceedings of the National Academy of Sciences, 113(37), pp. E5472–E5480. doi: 10.1073/pnas.1607571113.

  67. Naviaux, R.K. (2014) ‘Metabolic features of the cell danger response’, Mitochondrion, 16, pp. 7–17. doi: 10.1016/j.mito.2013.10.006.

  68. Naviaux, R.K. (2020) ‘Perspective: cell danger response biology—the new science that connects environmental health with mitochondria and the rising tide of chronic illness’, Mitochondrion, 51, pp. 40–45. doi: 10.1016/j.mito.2019.10.002.

  69. Naviaux, R.K. (2014) ‘Metabolic features of the cell danger response’, Mitochondrion, 16, pp. 7–17. doi: 10.1016/j.mito.2013.10.006.

  70. Shattuck, E.C. and Muehlenbein, M.P. (2015) ‘Human sickness behavior: ultimate and proximate explanations’, American Journal of Physical Anthropology, 157(1), pp. 1–18. doi: 10.1002/ajpa.22698.

  71. Nijhout, H.F. (1990) ‘Problems and paradigms: metaphors and the role of genes in development’, BioEssays, 12(9), pp. 441–446. doi: 10.1002/bies.950120908.

  72. Lipton, B.H. (2005) The Biology of Belief. California: Elite Books.

  73. (1) Cole, S.W. (2019) ‘The conserved transcriptional response to adversity’, Current Opinion in Behavioral Sciences, 28, pp. 31–37. doi: 10.1016/j.cobeha.2019.01.001; Dantzer, R. (2018) ‘A standardized social stress test increases IL-6 production via increased sympathetic outflow stimulating B2-adrenergic receptors on innate immune cells’, Physiological Reviews, 98, pp. 477–504. doi: 10.1152/physrev.00039.2016.

    (2) Freeman, R. and Komaroff, L. (1997) ‘Does the chronic fatigue syndrome involve the autonomic nervous system?’, The American Journal of Medicine, 102(4), pp. 357–364. doi: 10.1016/S0002-9343(97)00087-0.

    (3) Kraynak, T.E. et al. (2018) ‘Sympathetic nervous activity promotes proinflammatory gene transcription and cytokine production via beta-adrenergic receptor actions; parasympathetic activity has the opposite effect’, Neuroscience & Biobehavioral Reviews, 94, pp. 76–92. doi: 10.1016/j.neubiorev.2018.08.007.

    (4) Martinez, M., Mora, T., Vargas, A., Fuentes-Iniestra, M. and Martinez-Kavin, M. (2014) ‘Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: a review of case-control studies’, Journal of Clinical Rheumatology, 20(3), pp. 146–150. doi: 10.1097/RHU.0000000000000093.

    (5) Wyller, V.G., Eriksen, H.R. and Malterud, K. (2009) ‘Can sustained arousal explain the chronic fatigue syndrome?’, Behavioral and Brain Functions, 5(1), pp. 1–10. Available at:https://pubmed.ncbi.nlm.nih.gov/19236717/

  74. Selye, H. (1936) ‘A syndrome produced by diverse nocuous agents’, Nature, 138, p. 32. doi: 10.1038/138032a0.

  75. Lipton, B.H. (2005) The Biology of Belief. California: Elite Books.

  76. Polyvagal Institute (2025) Polyvagal Institute.

  77. Dana, D. (2018) The Polyvagal Theory in Therapy: Engaging the Rhythm of Regulation. Norton Series on Interpersonal Neurobiology. New York: W.W. Norton.

  78. Lipton, B.H. (2005) The Biology of Belief. California: Elite Books.

  79. Wyller, V.G., Eriksen, H.R. and Malterud, K. (2009) ‘Can sustained arousal explain the chronic fatigue syndrome?’, Behavioral and Brain Functions, 5(1), pp. 1–10. Available at:https://pubmed.ncbi.nlm.nih.gov/19236717/

  80. Sapolsky, R.M. (1995) Why Zebras Don’t Get Ulcers. New York: W.H. Freeman.

  81. Sapolsky, R.M. (1995) Why Zebras Don’t Get Ulcers. New York: W.H. Freeman.

  82. Van den Bergh, O., Brosschot, J., Critchley, H., Thayer, J.F. and Ottaviani, C. (2021) ‘Better safe than sorry: a common signature of general vulnerability for psychopathology’, Perspectives on Psychological Science, 16(2), pp. 225–246. doi: 10.1177/1745691620950690.

  83. Buczynski, R. and Porges, S. (2015) Transcript of: Polyvagal Theory Can Revolutionize Your Work with Trauma Survivors. Available at:https://www.nicabm.com

  84. Shonkoff, J. (2017) One million neural connections per second. Center on the Developing Child, Harvard University. Available at:https://developingchild.harvard.edu/science/key-concepts/brain-architecture/

  85. Heijmans, H. (1998) ‘Coping and adaptive outcome in chronic fatigue syndrome: importance of illness cognitions’, Journal of Psychosomatic Research, 45(1), pp. 39–51. doi: 10.1016/S0022-3999(97)00269-1.

  86. Jacobsen, H. and Reme, S. (2025) ‘Mind body reprocessing therapy for long COVID: theory and practice’, Authorea. Available at:https://www.authorea.com/users/938801/articles/1313568-mind-body-reprogramming-therapy-for-long-covid-theory-and-practice?commit=b616d3a483b858da40a009264ddb376cc671c275

  87. Nerli, T.F., Selvakumar, J., Cvejic, E. et al. (2024) ‘Brief outpatient rehabilitation program for post–COVID-19 condition: a randomized clinical trial’, JAMA Network Open, 7(12), e2450744. doi: 10.1001/jamanetworkopen.2024.50744.

  88. Hashmi, J.A., Baliki, M.N., Huang, L., Baria, A.T., Torbey, S., Hermann, K.M., Schnitzer, T.J. and Apkarian, A.V. (2013) ‘Shape shifting pain: chronification of back pain shifts brain representation from nociceptive to emotional circuits’, Brain, 136(9), pp. 2751–2768. doi: 10.1093/brain/awt211.

  89. Conversation with Vegard Wyller, March 2025.

  90. Boksem, M.A. and Tops, M. (2008) ‘Mental fatigue: costs and benefits’, Brain Research Reviews, 59(1), pp. 125–139. doi: 10.1016/j.brainresrev.2008.07.002.

  91. Kube, T., Rozenkrantz, L., Rief, W. and Barsky, A. (2020) ‘Understanding persistent physical symptoms: conceptual integration of psychological expectation models and predictive processing accounts’, Clinical Psychology Review, 76, p. 101829. doi: 10.1016/j.cpr.2020.101829.

  92. Kube, T., Rozenkrantz, L., Rief, W. and Barsky, A. (2020) ‘Understanding persistent physical symptoms: conceptual integration of psychological expectation models and predictive processing accounts’, Clinical Psychology Review, 76, p. 101829. doi: 10.1016/j.cpr.2020.101829.

  93. Van den Bergh, O., Witthöft, M., Petersen, S. and Brown, R.J. (2017) ‘Symptoms and the body: taking the inferential leap’, Neuroscience & Biobehavioral Reviews, 74, pp. 185–203. Available at:https://www.sciencedirect.com/science/article/abs/pii/S0149763416304729?via%3Dihub

  94. Azriel, O. and Bar-Haim, Y. (2020) ‘Attention bias’, Current Opinion in Psychology, 36, pp. 124–129. doi: 10.1016/j.copsyc.2020.05.004.

  95. Van den Bergh, O., Brosschot, J., Critchley, H., Thayer, J.F. and Ottaviani, C. (2021) ‘Better safe than sorry: a common signature of general vulnerability for psychopathology’, Perspectives on Psychological Science, 16(2), pp. 225–246. doi: 10.1177/1745691620950690.

  96. Van der Kolk, B. (2014) The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma. New York: Viking.

  97. Miller, A.H., Haroon, E., Raison, C.L. and Felger, J.C. (2017) ‘Cytokine targets in the brain: impact on neurocircuitry and behavior’, Neuroscience & Biobehavioral Reviews, 74(Pt A), pp. 276–290. doi: 10.1016/j.neubiorev.2016.12.023.

  98. Robson, D. (2022) The Expectation Effect. Edinburgh: Canongate Books.

  99. Kavanagh, K. (2025) ‘The brain fires up immune cells when sick people are nearby’, Nature, 644(8075), p. 17. doi: 10.1038/d41586-025-00123-4.

  100. Clark, A. (2016) Surfing Uncertainty: Prediction, Action and the Embodied Mind. New York: Oxford University Press.

  101. McEwen, B. and Lasley, E. (2002) The End of Stress as We Know It. New York: Dana Press.

  102. Selye, H. (1936) ‘A syndrome produced by diverse nocuous agents’, Nature, 138, p. 32. doi: 10.1038/138032a0.

  103. Schreiner, P. et al. (2020) ‘Human herpesvirus-6 reactivation, mitochondrial fragmentation, and the coordination of antiviral and metabolic phenotypes in myalgic encephalomyelitis/chronic fatigue syndrome’, ImmunoHorizons, 4(4), pp. 201–215. doi: 10.4049/immunohorizons.2000025.

  104. Papadopoulos, A. and Cleare, A. (2012) ‘Hypothalamic–pituitary–adrenal axis dysfunction in chronic fatigue syndrome’, Nature Reviews Endocrinology, 8, pp. 22–32. doi: 10.1038/nrendo.2011.153.

  105. (1) Fagundes, C.P. and Way, B. (2014) ‘Early-life stress and adult inflammation’, Current Directions in Psychological Science, 23(4), pp. 277–283. doi: 10.1177/0963721414535603.

    (2) Irwin, M.R. (2008) ‘Human psychoneuroimmunology: 20 years of discovery’, Brain, Behavior, and Immunity, 22(2), pp. 129–139. doi: 10.1016/j.bbi.2007.07.013.

    (3) Rohleder, N. (2019) ‘Stress and inflammation: the need to address the gap in the transition between acute and chronic stress effects’, Psychoneuroendocrinology, 105, pp. 164–171. doi: 10.1016/j.psyneuen.2019.02.021.

    (4) Cole, S.W. (2019) ‘The conserved transcriptional response to adversity’, Current Opinion in Behavioral Sciences, 28, pp. 31–37. doi: 10.1016/j.cobeha.2019.01.001.

    (5) Dantzer, R. (2018) ‘A standardized social stress test increases IL-6 production via increased sympathetic outflow stimulating B2-adrenergic receptors on innate immune cells’, Physiological Reviews, 98, pp. 477–504. doi: 10.1152/physrev.00039.2016.

    (6) Kraynak, T.E. et al. (2018) ‘Sympathetic nervous activity promotes proinflammatory gene transcription and cytokine production via beta-adrenergic receptor actions; parasympathetic activity has the opposite effect’, Neuroscience & Biobehavioural Reviews, 94, pp. 76–92.

  106. Sapolsky, R.M. (1995) Why Zebras Don’t Get Ulcers. New York: W.H. Freeman.

  107. McEwen, B. and Lasley, E. (2002) The End of Stress as We Know It. New York: Dana Press.

  108. Sapolsky, R.M. (1995) Why Zebras Don’t Get Ulcers. New York: W.H. Freeman.

  109. Cohen, S., Tyrrell, D.A.J. and Smith, A.P. (1991) ‘Psychological stress and susceptibility to the common cold’, New England Journal of Medicine, 325(9), pp. 606–612. doi: 10.1056/NEJM199108293250903.

  110. Kiecolt-Glaser, J.K. and Glaser, R. (1991) ‘Stress and immune function in humans’, in Ader, R., Felten, D.L. and Cohen, N. (eds.) Psychoneuroimmunology. 2nd edn. San Diego: Academic Press, pp. 849–867.

  111. Sapolsky, R.M. (1995) Why Zebras Don’t Get Ulcers. New York: W.H. Freeman.

  112. Buczynski, R. and Porges, S. (2015) Transcript of: Polyvagal Theory Can Revolutionize Your Work with Trauma Survivors. Available at:https://www.nicabm.com

  113. Jacobsen, H. and Reme, S. (2025) ‘Mind body reprocessing therapy for long COVID: theory and practice’, Authorea. Available at:https://www.authorea.com/users/938801/articles/1313568-mind-body-reprogramming-therapy-for-long-covid-theory-and-practice?commit=b616d3a483b858da40a009264ddb376cc671c275

  114. Buczynski, R. and Porges, S. (2015) Transcript of: Polyvagal Theory Can Revolutionize Your Work with Trauma Survivors. Available at:https://www.nicabm.com

  115. Dana, D. (2024) Anchored: How to Befriend Your Nervous System Using Polyvagal Theory. London: Vermilion (Penguin Random House UK).

    Chapter 3

  116. Vegard Wyller said in a presentation to COFFI: ‘Fatigue is a homeostatic alarm that activates the stress response systems’ (2025).

  117. Boruch, A.E., Barhorst, E.E., Rayne, T.J., Roberge, G.A., Brukardt, S.M., Leitel, Z.T., Coe, C.L., Fleshner, M., Falvo, M.J., Cook, D.B. and Lindheimer, J.B. (2024) ‘Exercise does not cause post-exertional malaise in veterans with Gulf War illness: a randomized, controlled, dose-response, crossover study’, Brain, Behavior, and Immunity – Health, 100708. doi: 10.1016/j.bbih.2024.100708; Tryfonos, M. et al. (2024) ‘Functional limitations and exercise intolerance in patients with post-COVID condition: a randomized crossover clinical trial’, JAMA Network Open, 7(11), e2439832. doi: 10.1001/jamanetworkopen.2024.39832.

  118. Donnino, M., Howard, P., Mehta, S., Silverman, J., Cabrera, M.J., Yamin, J.B., Balaji, L., Berg, K.M., Heydrick, S., Edwards, R. and Grossestreuer, A.V. (2023) ‘Psychophysiologic symptom relief therapy (PSRT) for post-acute sequelae of COVID-19’, Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 7(4), pp. 337–348. doi: 10.1016/j.mayocpiqo.2023.05.002.

  119. Nerli, T.F., Selvakumar, J., Cvejic, E. et al. (2024) ‘Brief outpatient rehabilitation program for post–COVID-19 condition: a randomized clinical trial’, JAMA Network Open, 7(12), e2450744. doi: 10.1001/jamanetworkopen.2024.50744.

  120. Kavanagh, K. (2025) ‘The brain fires up immune cells when sick people are nearby’, Nature, 644(8075), p. 17. doi: 10.1038/d41586-025-00123-4.

  121. Lipton, B. (2005) The Biology of Belief. California: Elite Books.

  122. Ader, R., Felten, D.L. and Cohen, N. (1991) Psychoneuroimmunology. 2nd edn. San Diego: Academic Press.

  123. Hall, N. and O’Grady, M. (1991) ‘Psychosocial interventions and immune function’, in Ader, R., Felten, D.L. and Cohen, N. (eds.) Psychoneuroimmunology. 2nd edn. San Diego: Academic Press, pp. 1067–1080. doi: 10.1016/B978-0-12-043780-1.50045-2.

  124. Krupnik, V. (2024) [Article title not provided], Frontiers in Neural Circuits, 18, p. 1283372. doi: 10.3389/fncir.2024.1283372; Tamburro, G. et al. (2020) [Article title not provided], Frontiers in Human Neuroscience, 14, p. 243. doi: 10.3389/fnhum.2020.00243.

  125. Pert, C. (1997) Molecules of Emotion. London: Simon and Schuster.

  126. Jentsch, V.L. and Wolf, O.T. (2020) ‘The impact of emotion regulation on cardiovascular, neuroendocrine and psychological stress responses’, Biological Psychology, 154, 107893. doi: 10.1016/j.biopsycho.2020.107893.

  127. Sapolsky, R.M. (1995) Why Zebras Don’t Get Ulcers. New York: W.H. Freeman.

  128. Crum, A.J., Salovey, P. and Achor, S. (2013) ‘Rethinking stress: the role of mindsets in determining the stress response’, Journal of Personality and Social Psychology, 104(4), p. 716; Crum, A.J., Akinola, M., Martin, A. and Fath, S. (2017) ‘The role of stress mindset in shaping cognitive, emotional, and physiological responses to challenging and threatening stress’, Anxiety, Stress, & Coping, 30(4), pp. 379–395. doi: 10.1080/10615806.2016.1275585.

  129. John-Henderson, N.A., Rheinschmidt, M.L. and Mendoza-Denton, R. (2015) ‘Cytokine responses and math performance: the role of stereotype threat and anxiety reappraisals’, Journal of Experimental Social Psychology, 56, pp. 203–206. doi: 10.1016/j.jesp.2014.10.002.

  130. Blascovich, J. and Mendes, W.B. (2010) ‘The role stress mindset in shaping cognitive, emotional, and physiological responses to challenging and threatening stress’.

  131. Doidge, N. (2007) The Brain That Changes Itself. New York: Viking Penguin.

  132. Doidge, N. (2007) The Brain That Changes Itself. New York: Viking Penguin.

  133. Taylor, J.B. (2009) My Stroke of Insight: A Brain Scientist’s Personal Journey. London: Hodder and Stoughton Ltd.

  134. Van der Kolk, B. (2015) The Body Keeps the Score: Brain, Mind, and Body in the Healing of Trauma. London: Penguin.

  135. YouTube (2009) M. Scott Peck – The Road Less Travelled. Available at:https://www.youtube.com/watch?v=xdNCAkfd0sg

  136. Reset to Thrive Training (2025) Webinar Replay: Committing to Your Recovery. Available at:https://www.youtube.com/watch?v=xdNCAkfd0sg

  137. TED (2022) How to Tap into Your Awareness | Yongey Mingyur Rinpoche | TED. Available at:https://www.youtube.com/watch?v=LDVyOnf0t9M

  138. Dana, D. (2024) Anchored: How to Befriend Your Nervous System Using Polyvagal Theory. London: Vermilion (Penguin Random House UK).

  139. Hasan, Z., Kuyvenhoven, C., Chowdhury, M., Amoudi, L., Zeraatkar, D., Busse, J.W., Sadik, M. and Vanstone, M. (2024) ‘Patient perspectives of recovery from myalgic encephalomyelitis/chronic fatigue syndrome: an interpretive description study’, Journal of Evaluation in Clinical Practice, 30(2), pp. 234–242. doi: 10.1111/jep.13938.

  140. Miller, A., Symington, F., Garner, P. and Pedersen, M. (2025) ‘Patients with severe ME/CFS need hope and expert multidisciplinary care’, BMJ, 389, p. 977. doi: 10.1136/bmj.r977.

  141. (1) Donnino, M., Howard, P., Mehta, S., Silverman, J., Cabrera, M.J., Yamin, J.B., Balaji, L., Berg, K.M., Heydrick, S., Edwards, R. and Grossestreuer, A.V. (2023) ‘Psychophysiologic symptom relief therapy (PSRT) for post-acute sequelae of COVID-19’, Mayo Clinic Proceedings: Innovations, Quality & Outcomes, 7(4), pp. 337–348. doi: 10.1016/j.mayocpiqo.2023.05.002.

    (2) Jacobsen, H. and Reme, S. (2025) ‘Mind body reprocessing therapy for long COVID: theory and practice’, Authorea. Available at:https://www.authorea.com/users/938801/articles/1313568-mind-body-reprogramming-therapy-for-long-covid-theory-and-practice?commit=b616d3a483b858da40a009264ddb376cc671c275 (Accessed: 15 December 2025).

    (3) Kikkenborg Berg, S., Dam Nielsen, S., Nygaard, U. et al. (2022) ‘Long COVID symptoms in SARS-CoV-2-positive adolescents and matched controls (LongCOVIDKidsDK): a national, cross-sectional study’, The Lancet Child & Adolescent Health, 6(4), pp. 240–248. doi: 10.1016/S2352-4642(22)00059-5.

    (4) Selvakumar, J., Havdal, L.B., Drevvatne, M. et al. (2023) ‘Prevalence and characteristics associated with post–COVID-19 condition among nonhospitalized adolescents and young adults’, JAMA Network Open, 6(3), e235763. doi: 10.1001/jamanetworkopen.2023.5763.

    (5) Stephenson, T., Pinto Pereira, S.M., Shafran, R. et al. (2022) ‘Physical and mental health 3 months after SARS-CoV-2 infection (CLoCk) among adolescents in England: a national matched cohort study’, The Lancet Child & Adolescent Health, 6(4), pp. 230–239. doi: 10.1016/S2352-4642(22)00022-7.

  142. Kuut, T.A., Müller, F., Csorba, I., Braamse, A., Aldenkamp, A., Appelman, B., Assmann-Schuilwerve, E., Geerlings, S.E., Gibney, K.B., Kanaan, R.A. and Mooij-Kalverda, K. (2023) ‘Efficacy of cognitive-behavioral therapy targeting severe fatigue following coronavirus disease 2019: results of a randomized controlled trial’, Clinical Infectious Diseases, 77(5), pp. 687–695. doi: 10.1093/cid/ciad325.

  143. (1) Bermpohl, F., Kucharczyk-Bodenburg, A.C. and Martin, A. (2024) ‘Efficacy and acceptance of cognitive behavioral therapy in adults with chronic fatigue syndrome: a meta-analysis’, International Journal of Behavioral Medicine, 31(6), pp. 895–910. doi: 10.1007/s12529-024-10241-3.

    (2) Gotaas, M.E., Stiles, T.C., Bjørngaard, J.H., Borchgrevink, P.C. and Fors, E.A. (2021) ‘Cognitive behavioral therapy improves physical function and fatigue in mild and moderate chronic fatigue syndrome: a consecutive randomized controlled trial of standard and short interventions’, Frontiers in Psychiatry, 12, p. 580924. doi: 10.3389/fpsyt.2021.580924.

    (3) Kuut, T.A., Buffart, L.M., Braamse, A.M.J., Csorba, I., Bleijenberg, G., Nieuwkerk, P., Moss-Morris, R., Müller, F. and Knoop, H. (2024) ‘Does the effect of cognitive behavior therapy for chronic fatigue syndrome (ME/CFS) vary by patient characteristics? A systematic review and individual patient data meta-analysis’, Psychological Medicine, 54(3), pp. 447–456. doi: 10.1017/S0033291723000742.

  144. de Gier, M., Picariello, F., Slot, M., Janse, A., Keijmel, S., Menting, J., Worm-Smeitink, M., Beckerman, H., de Groot, V., Moss-Morris, R. and Knoop, H. (2023) ‘The relation between cognitive-behavioural responses to symptoms in patients with long-term medical conditions and the outcome of cognitive behavioural therapy for fatigue – a secondary analysis of four RCTs’, Behaviour Research and Therapy, 161, p. 104243. doi: 10.1016/j.brat.2023.104243.

  145. McGregor, G., Sandhu, H., Bruce, J., Sheehan, B., McWilliams, D., Yeung, J., Jones, C., Lara, B., Alleyne, S., Smith, J. and Lall, R. (2024) ‘Clinical effectiveness of an online supervised group physical and mental health rehabilitation programme for adults with post-COVID-19 condition (REGAIN study): multicentre randomised controlled trial’, BMJ, 384, q1175. doi: 10.1136/bmj.q1175.

  146. Shields, G.S., Spahr, C.M. and Slavich, G.M. (2020) ‘Psychosocial interventions and immune system function: a systematic review and meta-analysis of randomized clinical trials’, JAMA Psychiatry, 77(10), pp. 1031–1043. doi: 10.1001/jamapsychiatry.2020.0431.

  147. Zeraatkar, D., Ling, M., Kirsh, S., Jassal, T., Shahab, M., Movahed, H., Talukdar, J.R., Walch, A., Chakraborty, S., Turner, T. and Turkstra, L. (2024) ‘Interventions for the management of long COVID (post-COVID condition): living systematic review’, BMJ, 387, 081318. doi: 10.1136/bmj-2024-081318.

  148. Zeraatkar, D., Ling, M., Kirsh, S., Jassal, T., Shahab, M., Movahed, H., Talukdar, J.R., Walch, A., Chakraborty, S., Turner, T. and Turkstra, L. (2024) ‘Interventions for the management of long COVID (post-COVID condition): living systematic review’, BMJ, 387, 081318. doi: 10.1136/bmj-2024-081318.

  149. Nakamura, K., Kondo, K., Oka, N. et al. (2025) ‘Donepezil for fatigue and psychological symptoms in post–COVID-19 condition: a randomized clinical trial’, JAMA Network Open, 8(3), e250728. doi: 10.1001/jamanetworkopen.2025.0728.

  150. Sawano, M., Bhattacharjee, B., Caraballo, C., Khera, R., Li, S.X., Herrin, J., Christian, D., Coppi, A., Warner, F., Holub, J. and Henriquez, Y. (2025) ‘Nirmatrelvir–ritonavir versus placebo–ritonavir in individuals with long COVID in the USA (PAX LC): a double-blind, randomised, placebo-controlled, phase 2, decentralised trial’, The Lancet Infectious Diseases. doi: 10.1016/S1473-3099(25)00045-7.

  151. Hunt, B.J., Kuehn, R., Fox, T., Carson, A., Scandrett, K., Davey Smith, G. and Garner, P. (2024) ‘Challenging the current hypothesis that thrombosis is responsible for the post-COVID-19 condition’, Research and Practice in Thrombosis and Haemostasis, 8(4), p. 102442. doi: 10.1016/j.rpth.2024.102442. Available at:https://pubmed.ncbi.nlm.nih.gov/38903154/ (Accessed: 12 December 2025).

  152. Hunt, B.J., Kuehn, R., Fox, T., Carson, A., Scandrett, K., Davey Smith, G. and Garner, P. (2024) ‘Challenging the current hypothesis that thrombosis is responsible for the post-COVID-19 condition’, Research and Practice in Thrombosis and Haemostasis, 8(4), p. 102442. doi: 10.1016/j.rpth.2024.102442. Available at:https://pubmed.ncbi.nlm.nih.gov/38903154/ (Accessed: 12 December 2025).

  153. Donnino, M.W., Thompson, G.S., Mehta, S., Paschali, M., Howard, P., Antonsen, S.B., Balaji, L., Bertisch, S.M., Edwards, R., Ngo, L.H. and Grossestreuer, A.V. (2021) ‘Psychophysiologic symptom relief therapy for chronic back pain: a pilot randomized controlled trial’, Pain Reports, 6(3), p. e959.

  154. Yarns, B.C., Jackson, N.J., Alas, A., Melrose, R.J., Lumley, M.A. and Sultzer, D.L. (2024) ‘Emotional awareness and expression therapy vs cognitive behavioral therapy for chronic pain in older veterans: a randomized clinical trial’, JAMA Network Open, 7(6), pp. e2415842–e2415842.

  155. Hsu, M.C., Schubiner, H., Lumley, M.A., Stracks, J.S., Clauw, D.J. and Williams, D.A. (2010) ‘Sustained pain reduction through affective self-awareness in fibromyalgia: a randomized controlled trial’, Journal of General Internal Medicine, 25(10), pp. 1064–1070.

  156. Frisk, B., Jürgensen, M., Espehaug, B., Søfteland, E. and Kvale, G. (2025) ‘Sustained improvements in sick leave, fatigue and functional status following a concentrated micro-choice based treatment for patients with long COVID: a 1 year prospective uncontrolled study’, Journal of Psychosomatic Research, 189, p. 112023. doi: 10.1016/j.jpsychores.2024.112023.

  157. Nerli, T.F., Selvakumar, J., Cvejic, E. et al. (2024) ‘Brief outpatient rehabilitation program for post–COVID-19 condition: a randomized clinical trial’, JAMA Network Open, 7(12), e2450744. doi: 10.1001/jamanetworkopen.2024.50744.

  158. Casson, S., Jones, M.D., Cassar, J., Kwai, N., Lloyd, A.R., Barry, B.K. and Sandler, C.X. (2023) ‘The effectiveness of activity pacing interventions for people with chronic fatigue syndrome: a systematic review and meta-analysis’, Disability and Rehabilitation, 45(23), pp. 3788–3802. doi: 10.1080/09638288.2022.2135776.

  159. Boruch, A.E., Barhorst, E.E., Rayne, T.J., Roberge, G.A., Brukardt, S.M., Leitel, Z.T., Coe, C.L., Fleshner, M., Falvo,M.J., Cook, D.B. and Lindheimer, J.B. (2024) ‘Exercise does not cause post-exertional malaise in veterans with Gulf War illness: a randomized, controlled, dose-response, crossover study’, Brain, Behavior, and Immunity – Health. doi: 10.1016/j.bbih.2024.100708.

  160. Tryfonos, M. et al. (2024) ‘Functional limitations and exercise intolerance in patients with post-COVID condition: a randomized crossover clinical trial’, JAMA Network Open, 7(11), e2439832. doi: 10.1001/jamanetworkopen.2024.39832.

    Chapter 4

  161. Buczynski, R. and Porges, S. (2015) Transcript of: “Polyvagal Theory Can Revolutionize Your Work with Trauma Survivors”. Available at:www.nicabm.com

  162. Buczynski, R. and Porges, S. (2014) Transcript of: “How Polyvagal Theory Expands Our Healing Paradigm”. Available at:www.nicabm.com

  163. (1) Azriel, O. and Bar-Haim, Y. (2020) ‘Attention bias’, in Abramowitz, J.S. and Blakey, S.M. (eds.) Clinical Handbook of Fear and Anxiety: Maintenance Processes and Treatment Mechanisms. Washington, DC: American Psychological Association, pp. 203–218. doi: 10.1037/0000150-012.

    (2) Rehm, S., Sachau, J., Hellriegel, J. et al. (2021) ‘Pain matters for central sensitization: sensory and psychological parameters in patients with fibromyalgia syndrome’, Pain Reports, 6(1), e901. doi: 10.1097/PR9.0000000000000901.

    (3) Van den Bergh, O., Witthöft, M., Petersen, S. and Brown, R.J. (2017) ‘Symptoms and the body: taking the inferential leap’, Neuroscience & Biobehavioral Reviews, 74, pp. 185–203. doi: 10.1016/j.neubiorev.2016.12.017.

  164. Commmunicatiewetenschappen (2017) Test Your Awareness: Who Dunnit. Available at:https://www.youtube.com/watch?v=LRFMuGBP15U

  165. Pert, C. (1997) Molecules of Emotion: The Science Behind Mind-Body Medicine. London: Simon & Schuster.

  166. Hunt-Davis, B. and Beveridge, H. (2011) Will It Make the Boat Go Faster? Leicester: Matador.

  167. Nerli, T.F., Selvakumar, J., Cvejic, E. et al. (2024) ‘Brief outpatient rehabilitation program for post–COVID-19 condition: a randomized clinical trial’, JAMA Network Open, 7(12), e2450744. doi: 10.1001/jamanetworkopen.2024.50744.

  168. Reeve, S. (2019) Step By Step. London: Hodder and Stoughton.

  169. Moseley, M. (2018) Trust Me, I’m a Doctor: Mental Health Special. BBC Two. Available at:www.bbc.co.uk

  170. Reset to Thrive Training (2025) Webinar Replay: Committing to Your Recovery. Available at:https://www.youtube.com/watch?v=xdNCAkfd0sg

  171. Buczynski, R. and Porges, S. (2015) Transcript of: “Polyvagal Theory Can Revolutionize Your Work with Trauma Survivors”. Available at:www.nicabm.com (Accessed: 17 December 2025).

  172. Taylor, J.B. (2009) My Stroke of Insight: A Brain Scientist’s Personal Journey. London: Hodder and Stoughton Ltd.

  173. Scott, D.J., Stohler, C.S., Egnatuk, C.M., Wang, H., Koeppe, R.A. and Zubieta, J.K. (2008) ‘Placebo and nocebo effects are defined by opposite opioid and dopaminergic responses’, Archives of General Psychiatry, 65(2), pp. 220–231. doi: 10.1001/archgenpsychiatry.65.2.220.

  174. Mark, J.I., Cunningham, D. and Cassidy, J.M. (2025) ‘Advancing stroke recovery through operant conditioning of corticomuscular coherence’, Restorative Neurology and Neuroscience, p. 09226028251379344. doi: 10.3233/RNN-250344.

  175. Thompson, A.K. and Wolpaw, J.R. (2015) ‘Restoring walking after spinal cord injury: operant conditioning of spinal reflexes can help’, The Neuroscientist, 21(2), pp. 203–215. doi: 10.1177/1073858414527541.

  176. Nerli, T.F., Selvakumar, J., Cvejic, E. et al. (2024) ‘Brief outpatient rehabilitation program for post–COVID-19 condition: a randomized clinical trial’, JAMA Network Open, 7(12), e2450744. doi: 10.1001/jamanetworkopen.2024.50744.

  177. Boksem, M.A.S. and Tops, M. (2008) ‘Mental fatigue: costs and benefits’, Brain Research Reviews, 59(1), pp. 125–139. doi: 10.1016/j.brainresrev.2008.07.002.

  178. Naviaux, R.K. (2020) ‘Perspective: cell danger response biology—the new science that connects environmental health with mitochondria and the rising tide of chronic illness’, Mitochondrion, 51, pp. 40–45. doi: 10.1016/j.mito.2019.12.005.

  179. Selye, H. (1936) ‘A syndrome produced by diverse nocuous agents’, Nature, 138, p. 32. doi: 10.1038/138032a0.

  180. Harvard Gazette (2017) ‘Harvard Study of Adult Development: the key to living a happy life’, Harvard Gazette, 11 April. Available at:https://news.harvard.edu/gazette/story/2017/04/over-nearly-80-years-harvard-study-has-been-showing-how-to-live-a-healthy-and-happy-life

  181. Hu, T., Zhang, D. and Wang, J. (2015) ‘A meta-analysis of the trait resilience and mental health’, Personality and Individual Differences, 76, pp. 18–27. doi: 10.1016/j.paid.2014.11.039.

  182. Stewart, D.E. and Yuen, T. (2011) ‘A systematic review of resilience in the physically ill’, Psychosomatics, 52(3), pp. 199–208. doi: 10.1016/j.psym.2011.01.036; Ludolph, P., Kunzler, A.M., Stoffers-Winterling, J., Helmreich, I. and Lieb, K. (2019) ‘Interventions to promote resilience in cancer patients’, Deutsches Ärzteblatt International, 116(51–52), p. 865. doi: 10.3238/arztebl.2019.0865.

  183. Stewart, D.E. and Yuen, T. (2011) ‘A systematic review of resilience in the physically ill’, Psychosomatics, 52(3), pp. 199–208. doi: 10.1016/j.psym.2011.01.036.

  184. Hamilton, D. (2015) I Heart Me: The Science of Self Love. Hay House Ltd.

  185. Van den Bergh, O. et al. (2017) ‘Symptoms and the body: taking the inferential leap’, Neuroscience & Biobehavioral Reviews, 74, pp. 185–203. 

    Chapter 5

  186. Boksem, M.A. and Tops, M. (2008) ‘Mental fatigue: costs and benefits’, Brain Research Reviews, 59(1), pp. 125–139.

  187. (1) Ardestani, S.K., Karkhaneh, M., Stein, E., Punja, S., Junqueira, D.R., Kuzmyn, T., Pearson, M., Smith, L., Olson, K. and Vohra, S. (2021) ‘Systematic review of mind-body interventions to treat myalgic encephalomyelitis/chronic fatigue syndrome’, Medicina, 57(7), p. 652. doi: 10.3390/medicina57070652.
    (2) Gerbarg, P.L. and Brown, R.P. (2021) ‘Mind-body interventions to reduce coronavirus pandemic stress and support long-term recovery’, NYMC Faculty Publications, Paper 4648. Available at:https://touroscholar.touro.edu/nymc_fac_pubs/4648
    (3) Neuronium (2024) ‘Vagus nerve and chronic fatigue syndrome: a neuroimmunological perspective’, Neuronium, 23 March. Available at:https://www.neuronium.org/vagus-nerve-and-chronic-fatigue-syndrome/

  188. (1) SelfHacked (2015) ‘32 ways to stimulate your vagus nerve (and symptoms of vagal dysfunction)’. Available at: https://selfhacked.com/blog/28-ways-to-stimulate-your-vagus-nerve-and-all-you-need-to-know-about-it
    (2) Tanaka, M., Tajima, S., Mizuno, K., Ishii, A., Konishi, Y., Mike, Y. and Watanabe, Y. (2015) ‘Frontier studies on fatigue, autonomic nerve dysfunction, and sleep-rhythm disorder’, The Journal of Physiological Science, 65(6), pp. 483–498.
    (3) Mason, H., Vandoni, M., deBarbieri, G., Codrons, E., Ugargol, V. and Bernardi, L. (2013) ‘Cardiovascular and respiratory effect of yogic slow breathing in the yoga beginner: what is the best approach?’, Evidence-Based Complementary and Alternative Medicine.
    (4) Ottani, A., Giuliani, D., Galantucci, M., Spaccapelo, L., Novelino, E., Grieco, P., Jochem, J. and Guarini, S. (2010) ‘Melanocortins counteract inflammatory and apoptotic responses to prolonged myocardial ischemia/reperfusion through a vagus nerve-mediated mechanism’, European Journal of Pharmacology, 637(1–3), pp. 124–130.
    (5) Earl, N. (2017) ‘Relaxation 101: how to activate the parasympathetic nervous system’, HealthVibed. Available at:http://healthvibed.com/relaxation-101-how-to-activate-the-pns/#content6

  189. Ballard, C. (2025) ‘How to age like an athlete’, National Geographic, 248, October. Section: ‘Calm your mind, push your limits’. 

  190. Cleare, A.J. (2004) ‘The HPA axis and the genesis of chronic fatigue syndrome’, Trends in Endocrinology & Metabolism, 15(2), pp. 55–59. doi: 10.1016/j.tem.2003.12.002.

  191. (1) Zou, Y., Wu, Q., Liu, T., Wang, J.Y., Liu, L. and Wang, X.H. (2022) ‘The effect of slow breathing exercise on heart rate and blood pressure in patients undergoing percutaneous coronary intervention: a randomized controlled trial’, European Journal of Cardiovascular Nursing, 21(3), pp. 271–279.
    (2) Yuenyongchaiwat, K., Changsri, K., Harnmanop, S., Namdaeng, P., Aiemthaisong, M., Pongpanit, K. and Pariyatkaraphan, T. (2024) ‘Effects of slow breathing training on hemodynamic changes, cardiac autonomic function and neuroendocrine response in people with high blood pressure: a randomized control trial’, Journal of Bodywork and Movement Therapies, 37, pp. 136–141.
    (3) Kavitha, N., Pal, P., Pal, G.K., Bharadwaj, B. and Nanda, N. (2024) ‘Effects of slow breathing exercises on cardiac autonomic functions in anxiety disorder—a randomised control trial’, Annals of Neurosciences, p. 09727531241266094.
    (4) Larson, M., Chantigian, D.P., Asirvatham-Jeyaraj, N., Van de Winckel, A. and Keller-Ross, M.L. (2020) ‘Slow-paced breathing and autonomic function in people post-stroke’, Frontiers in Physiology, 11, p. 573325.
    (5) Balint, E.M., Grüner, B., Gündel, H., Haase, S., Kaw-Geppert, M., Thayer, J., Weimer, K. and Jarczok, M.N. (2025) ‘Acute effects of slow-paced breathing on measures of HRV in hospitalized patients with bilateral COVID-19 pneumonia: a secondary analysis of a randomized clinical trial’, Biopsychosocial Science and Medicine, 87(1), pp. 74–83.
    (6) Modesti, P.A., Ferrari, A., Bazzini, C. and Boddi, M. (2015) ‘Time sequence of autonomic changes induced by daily slow-breathing sessions’, Clinical Autonomic Research, 25(2), pp. 95–104.
    (7) Chinagudi, S. et al. (2014) ‘Immediate effect of short duration of slow deep breathing on heart rate variability in healthy adults’, National Journal of Physiology, Pharmacy and Pharmacology, 4(3), pp. 233–235.

  192. Robson, D. (2022) The Expectation Effect. Edinburgh: Canongate Books.

  193. Chinagudi, S. et al. (2014) ‘Immediate effect of short duration of slow deep breathing on heart rate variability in healthy adults’, National Journal of Physiology, Pharmacy and Pharmacology, 4(3), pp. 233–235.

  194. Boksem, M.A. and Tops, M. (2008) ‘Mental fatigue: costs and benefits’, Brain Research Reviews, 59(1), pp. 125–139

  195. (1) Mark, J.I., Cunningham, D. and Cassidy, J.M. (2025) ‘Advancing stroke recovery through operant conditioning of corticomuscular coherence’, Restorative Neurology and Neuroscience, p. 09226028251379344.
    (2) Nerli, T.F., Selvakumar, J., Cvejic, E., Heier, I., Pedersen, M., Johnsen, T.L. and Wyller, V.B.B. (2024) ‘Brief outpatient rehabilitation program for post–COVID-19 condition: a randomized clinical trial’, JAMA Network Open, 7(12), pp. E2450744–e2450744.
    (3) Jacobsen, H. and Reme, S. (2025) ‘Mind body reprocessing therapy for Long Covid: theory and practice’. Available at:https://www.authorea.com/users/938801/articles/1313568-mind-body-reprogramming-therapy-for-long-covid-theory-and-practice?commit=b616d3a483b858da40a009264ddb376cc671c275

  196. Boksem, M.A. and Tops, M. (2008) ‘Mental fatigue: costs and benefits’, Brain Research Reviews, 59(1), pp. 125–139.

  197. (1) Ranganathan, V.K., Siemionow, V., Liu, J.Z., Sahgal, V. and Yue, G.H. (2004) ‘From mental power to muscle power: gaining strength by using the mind’, Neuropsychologia, 42(7), pp. 944–956. doi: 10.1016/j.neuropsychologia.2003.11.018. PMID: 14998709.
    (2) Yao, W.X., Ranganathan, V.K., Allexandre, D., Siemionow, V. and Yue, G.H. (2013) ‘Kinesthetic imagery training of forceful muscle contractions increases brain signal and muscle strength’, Frontiers in Human Neuroscience, 7, p. 561. doi: 10.3389/fnhum.2013.00561. PMID: 24133427; PMCID: PMC3783980. Available at:https://pmc.ncbi.nlm.nih.gov/articles/PMC3783980/
    (3) Yue and Cole, 1992; Yue et al., 1996; Smith et al., 2003; Zijdewind et al., 2003; Ranganathan et al., 2004; Sidaway and Trzaska, 2005; Shackell and Standing, 2007.

  198. Buzzard, G. (2022) ‘Learn from Michael Phelps and build a strong mental game’, Medium, 30 January. Available at: https://medium.com/change-your-mind/learn-from-michael-phelps-and-build-a-strong-mental-game-6f1ba9a23d55 

  199. Mosley, M. (2018) Trust Me, I’m a Doctor: Mental Health Special. BBC Two. Available at:www.bbc.co.uk

  200. Van den Bergh, O., Witthöft, M., Petersen, S. and Brown, R.J. (2017) ‘Symptoms and the body: taking the inferential leap’, Neuroscience & Biobehavioral Reviews, 74, pp. 185–203. Available at:https://www.sciencedirect.com/science/article/abs/pii/S0149763416304729?via%3Dihub

  201. Dinsmore-Tuli, U. and Tuli, N. (2022) Yoga Nidra Made Easy: Deep Relaxation Practices to Improve Sleep, Relieve Stress and Boost Energy and Creativity. Hay House.

    Chapter 6

  202. Kube, T., Rozenkrantz, L., Rief, W. and Barsky, A. (2020) ‘Understanding persistent physical symptoms: conceptual integration of psychological expectation models and predictive processing accounts’, Clinical Psychology Review, 76, p. 101829. doi: 10.1016/j.cpr.2020.101829.

  203. Azriel, O. and Bar-Haim, Y. (2020) ‘Attention bias’, in Abramowitz, J.S. and Blakey, S.M. (eds.) Clinical Handbook of Fear and Anxiety: Maintenance Processes and Treatment Mechanisms. Washington, DC: American Psychological Association, pp. 203–218. doi: 10.1037/0000150-012.

  204. Van den Bergh, O., Witthöft, M., Petersen, S. and Brown, R.J. (2017) ‘Symptoms and the body: taking the inferential leap’, Neuroscience & Biobehavioral Reviews, 74, pp. 185–203. Available at:https://www.sciencedirect.com/science/article/abs/pii/S0149763416304729?via%3Dihub

  205. Van den Bergh, O., Brosschot, J., Critchley, H., Thayer, J.F. and Ottaviani, C. (2021) ‘Better safe than sorry: a common signature of general vulnerability for psychopathology’, Perspectives on Psychological Science, 16(2), pp. 225–246. doi: 10.1177/1745691620950690

    Chapter 7

  206. McEwen, B. and Lasley, E. (2002) The End of Stress as We Know It. New York: Dana Press. 

  207. Friedberg, F., Leung, D.W. and Quick, J. (2005) ‘Do support groups help people with chronic fatigue syndrome and fibromyalgia? A comparison of active and inactive members’, The Journal of Rheumatology, 32(12), pp. 2416–2420.

  208. Brown, B., Huszar, K. and Chapman, R. (2017) ‘“Betwixt and between”: liminality in recovery stories from people with myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS)’, Sociology of Health & Illness, 39(5), pp. 696–710. doi: 10.1111/1467-9566.12546.

  209. (1) Harlow, H.F. and Zimmerman, R. (1958) ‘The development of affectional responses in infant monkeys’, Proceedings of the American Philosophical Society, 102(5), pp. 501–509.
    (2) Bowlby, J. and Ainsworth, M. (1992) ‘The origins of attachment theory’, Developmental Psychology, 28, pp. 759–775. Routledge.

  210. Holt-Lunstad, J. (2020) ‘Social isolation and health’, Health Affairs Brief. Available at:https://www.healthaffairs.org/do/10.1377/hpb20200622.253235/

  211. (1) Holt-Lunstad, J., Smith, T. and Bradley Layton, J. (2010) ‘Social relationships and mortality risk: a meta-analytic review’, PLOS Medicine, 7(7), p. E1000316.
    (2) Holt-Lunstad, J., Smith, T.B., Baker, M., Harris, T. and Stephenson, D. (2015) ‘Loneliness and social isolation as risk factors for mortality’, Perspectives on Psychological Science, 10(2), pp. 227–237. doi: 10.1177/1745691614568352.

  212. Kiecolt-Glaser, J. and Glaser, R. (1991) ‘Stress and immune function in humans’, in Psychoneuroimmunology. 2nd edn. San Diego: Academic Press, pp. 849–867.

  213. Naviaux, R. (2020) ‘Perspective: cell danger response biology’, Mitochondrion, 51(3), pp. 40–45. Available at:https://www.sciencedirect.com/science/article/pii/S1567724919302922

  214. Matison, A.P., Samtani, S., Brodaty, H., Sachdev, P.S. and Reppermund, S. (2025) ‘How well do social frailty indices predict incident dementia in older adults?’, The Journals of Gerontology: Series B, 80(10), gbaf148. doi: 10.1093/geronb/gbaf148.

  215. Harvard Study of Adult Development (2017) ‘The key to living a happy life’, Harvard Gazette, 11 April. Available at:https://news.harvard.edu/gazette/story/2017/04/over-nearly-80-years-harvard-study-has-been-showing-how-to-live-a-healthy-and-happy-life/

  216. Petersen, H. (2021) Can’t Even: How Millennials Became the Burnt Out Generation. New York: Random House.

  217. Office for National Statistics (ONS) (2020) ‘Parenting in lockdown: coronavirus and the effects on work-life balance’. Available at: https://www.ons.gov.uk/peoplepopulationandcommunity/healthandsocialcare/conditionsanddiseases/datasets/parentinginlockdowncoronavirusandtheeffectsonworklifebalance

  218. Rudd, M. (2020) Man Down: Why Men Are Unhappy and What We Can Do About It. UK: Piatkus.

  219. Patterson, C. (2020) ‘Man Down by Matt Rudd, review: why are men unhappy?’, The Sunday Times Magazine, 20 September. Available at:https://www.thetimes.co.uk/article/man-down-why-men-are-unhappy-and-what-we-can-do-about-it-by-matt-rudd-book-review-nvm2phd2x

  220. Moldofsky, H. (1993) ‘Fibromyalgia, sleep disorder and chronic fatigue syndrome’, in Whelan, J. and Bock, G. (eds.) Chronic Fatigue Syndrome. London: Wiley, pp. 262–271.

  221. Moldofsky, H. (1993) ‘Fibromyalgia, sleep disorder and chronic fatigue syndrome’, in Whelan, J. and Bock, G. (eds.) Chronic Fatigue Syndrome. London: Wiley, pp. 262–271.

  222. Naviaux, R. (2020) ‘Perspective: cell danger response biology’, Mitochondrion, 51(3), pp. 40–45. Available at:https://www.sciencedirect.com/science/article/pii/S1567724919302922

  223. Van Tulleken, C. (2024) Ultra-Processed People: Why Do We All Eat Stuff That Isn’t Food... and Why Can’t We Stop? London: Penguin

  224. Spector, T. (2024) Food for Life: Your Guide to the New Science of Eating Well. Vintage. Available at:https://english.emmaclit.com/2017/05/20/you-shouldve-asked/

  225. The Association of Neuroplastic Symptoms (no date). Available at:https://www.symptomatic.me/

  226. Sapolsky, R.M. (1995) Why Zebras Don’t Get Ulcers. New York: W.H. Freeman.

  227. McCrossin, R. (2022) ‘Finding the true number of females with autistic spectrum disorder by estimating the biases in initial recognition and clinical diagnosis’, Children, 9(2), p. 272.

  228. (1) National Autistic Society (no date) ‘Masking’. Available at:https://www.autism.org.uk/advice-and-guidance/behaviour/masking
    (2) McKinney, A., O’Brien, S., Maybin, J.A., Chan, S.W.Y., Richer, S. and Rhodes, S. (2024) ‘Camouflaging in neurodivergent and neurotypical girls at the transition to adolescence and its relationship to mental health: a participatory methods research study’, JCPP Advances, 4(4), e12294. doi: 10.1002/jcv2.12294.
    (3) Dolan, I. (2026) Masking in Autistic Adults: A Clinician’s Guide to Neurodiversity-Affirming Care. Taylor & Francis.

  229. Estes, C. ‘Coercive control’. Available at:https://www.healthline.com/health/coercive-control

  230. Barlow, C., Walklate, S., Johnson, K., Humphreys, L. and Kirby, S. (2018) Police Responses to Coercive Control. N8 Policing Research Partnership.

  231. Kiecolt-Glaser, J. and Glaser, R. (1991) ‘Stress and immune function in humans’, in Psychoneuroimmunology. 2nd edn. San Diego: Academic Press, pp. 849–867.

  232. Friedberg, F., Leung, D.W. and Quick, J. (2005) ‘Do support groups help people with chronic fatigue syndrome and fibromyalgia? A comparison of active and inactive members’, The Journal of Rheumatology, 32(12), pp. 2416–2420.

  233. (1) Holt-Lunstad, J., Smith, T. and Bradley Layton, J. (2010) ‘Social relationships and mortality risk: a meta-analytic review’, PLOS Medicine, 7(7), p. e1000316.
    (2) Kiecolt-Glaser, J. and Glaser, R. (1991) ‘Stress and immune function in humans’, in Psychoneuroimmunology. 2nd edn. San Diego: Academic Press, pp. 849–867.

  234. Friedberg, F., Leung, D.W. and Quick, J. (2005) ‘Do support groups help people with chronic fatigue syndrome and fibromyalgia? A comparison of active and inactive members’, The Journal of Rheumatology, 32(12), pp. 2416–2420.

  235. Brown, B., Huszar, K. and Chapman, R. (2017) ‘“Betwixt and between”: liminality in recovery stories from people with myalgic encephalomyelitis (ME) or chronic fatigue syndrome (CFS)’, Sociology of Health & Illness, 39(5), pp. 696–710. doi: 10.1111/1467-9566.12546.

  236. Dunbar, R. (2021) Friends: Understanding the Power of Our Most Important Relationships. London: Little Brown.

  237. Harvard Gazette (2017) Available at:https://news.harvard.edu/gazette/story/2017/04/over-nearly-80-years-harvard-study-has-been-showing-how-to-live-a-healthy-and-happy-life/

  238. Harvard Study of Adult Development (2017) ‘The key to living a happy life’, Harvard Gazette, 11 April. Available at:https://news.harvard.edu/gazette/story/2017/04/over-nearly-80-years-harvard-study-has-been-showing-how-to-live-a-healthy-and-happy-life

  239. National Geographic, 248, October 2025.

  240. Perry, B.D. and Szalavitz, M. (2017) The Boy Who Was Raised as a Dog: And Other Stories from a Child Psychiatrist’s Notebook: What Traumatized Children Can Teach Us About Loss, Love, and Healing. Basic Books.

  241. Rogers, C.R. (1961) On Becoming a Person: A Therapist’s View of Psychotherapy. Boston: Houghton-Mifflin.

  242. Lancaster, K., Bhopti, A., Kern, M.L., Taylor, R., Janson, A. and Harding, K. (2023) ‘Effectiveness of peer support programmes for improving wellbeing and quality of life in parents and carers of children with disability or chronic illness’, Child Care Health and Development, 49(3), pp. 485–496. Available at:https://onlinelibrary.wiley.com/doi/full/10.1111/cch.13063

  243. Meltzer, D.O., Best, T.J., Zhang, H., Vokes, T., Arora, V. and Solway, J. (2020) ‘Association of vitamin D deficiency and treatment with COVID-19 incidence’, medRxiv. doi: 10.1101/2020.05.08.20095893.

  244. Brenner, H. and Schöttker, B. (2020) ‘Vitamin D insufficiency may account for almost nine of ten COVID-19 deaths: time to act. Comment on: “Vitamin D deficiency and outcome of COVID-19 patients”’, Nutrients, 12(12), p. 3642. doi: 10.3390/nu12123642.

  245. Spector, T. (2024) Food for Life: Your Guide to the New Science of Eating Well. Vintage.

  246. Schoenfeld (2025) National Geographic, 248, October.

  247. Diamond, K. (2024) ‘Mindfulness as an intervention for self-regulation and school reintegration in a trauma-informed primary school post COVID-19 lockdown’, Mindfulness, 15(8), pp. 2023–2037.

  248. Pandey, A., Hale, D., Das, S., Goddings, A.L., Blakemore, S.J. and Viner, R.M. (2018) ‘Effectiveness of universal self-regulation-based interventions in children and adolescents: a systematic review and meta-analysis’, JAMA Pediatrics, 172(6), pp. 566–575.

  249. Hofmann, S.G. and Gómez, A.F. (2017) ‘Mindfulness-based interventions for anxiety and depression’, The Psychiatric Clinics of North America, 40(4), p. 739.

  250. Catanese, L. (2024) Self-Regulation for Adults: Strategies for Getting a Handle on Emotions and Behavior.

  251. Cameron, L.D., Carroll, P. and Hamilton, W.K. (2018) ‘Evaluation of an intervention promoting emotion regulation skills for adults with persisting distress due to adverse childhood experiences’, Child Abuse & Neglect, 79, pp. 423–433.

  252. The Association of Neuroplastic Symptoms (no date) ‘About us’. Available at:https://www.symptomatic.me/about-us

  253. Levine, P. (1997) Waking the Tiger: Healing the Trauma: The Innate Capacity to Transform Overwhelming Experiences. North Atlantic Books.

  254. Goleman, D. (2003) Destructive Emotions and How We Can Overcome Them: A Dialogue with the Dalai Lama. Bloomsbury Publishing UK/International and Bantam USA.

  255. Conscious.is (no date) Meditations. Available at:https://conscious.is/resources/meditations

  256. Chill UK (no date). Available at:https://chilluk.org

    Chapter 8

  257. McEwen, B. and Lasley, E. (2002) The End of Stress as We Know It. New York: Dana Press.

  258. Goertzel, B.N. et al. (2006) ‘Combinations of single nucleotide polymorphisms in neuroendocrine effector and receptor genes predict chronic fatigue syndrome’, Future Medicine Ltd, 7(3), pp. 475–483. doi: 10.2217/14622416.7.3.475.

  259. Maloney, E.M. et al. (2006) ‘Chronic fatigue syndrome and high allostatic load’, Future Medicine Ltd, 7(3), pp. 467–473. doi: 10.2217/14622416.7.3.467.

  260. Sapolsky, R.M. (1995) Why Zebras Don’t Get Ulcers. New York: W.H. Freeman; Buczynski, R. and Porges, S. (2015) Transcript of: “Polyvagal Theory Can Revolutionize Your Work with Trauma Survivors”. Available at:www.nicabm.com

  261. Porges, S.W. (2001) ‘The polyvagal theory: phylogenetic substrates of a social nervous system’, International Journal of Psychophysiology, 42(2), pp. 123–146. Elsevier.

  262. Porges, S.W. (2001) ‘The polyvagal theory: phylogenetic substrates of a social nervous system’, International Journal of Psychophysiology, 42(2), pp. 123–146. Elsevier.

  263. Buczynski, R. and Porges, S. (2014) Transcript of: How Polyvagal Theory Expands Our Healing Paradigm, p. 12. Available at:www.nicabm.com

  264. Buczynski, R. and Porges, S. (2015) Transcript of: “Polyvagal Theory Can Revolutionize Your Work with Trauma Survivors”, p. 15. Available at:www.nicabm.com

  265. Porges, S. (2011) The Polyvagal Theory: Neurophysiological Foundations of Emotion, Attachment, Communication, and Self-Regulation. New York: W.W. Norton, p. 265.

  266. Sapolsky, R.M. (1995) Why Zebras Don’t Get Ulcers. New York: W.H. Freeman.

  267. The Association of Neuroplastic Symptoms (no date). Available at:https://www.symptomatic.me/

  268. Goleman, D. (2003) Destructive Emotions and How We Can Overcome Them: A Dialogue with the Dalai Lama. Bloomsbury Publishing UK/International and Bantam USA.

  269. Hamilton, D. (2015) I Heart Me: The Science of Self Love. Hay House Ltd.

  270. Porges, S.W. (2001) ‘The polyvagal theory: phylogenetic substrates of a social nervous system’, International Journal of Psychophysiology, 42(2), pp. 123–146. Elsevier.

  271. (1) Holt-Lunstad, J., Smith, T. and Bradley Layton, J. (2010) ‘Social relationships and mortality risk: a meta-analytic review’, PLOS Medicine, 7(7), p. e1000316.
    (2) Kiecolt-Glaser, J.K. and Wilson, S.J. (2017) ‘Lovesick: how couples’ relationships influence health’, Annual Review of Clinical Psychology, 13, pp. 421–443. doi: 10.1146/annurev-clinpsy-032816-045111.

    Chapter 9

  272. Hill, P.L. and Turiano, N.A. (2014) ‘Purpose in life as a predictor of mortality across adulthood’, Psychological Science, 25(7), pp. 1482–1486. doi: 10.1177/0956797614531799.

  273. Hill, P., Burrow, A., Brandenberger, J., Lapsley, D. and Quaranto, J. (2010) ‘Collegiate purpose orientations and well-being in adulthood’, Journal of Applied Developmental Psychology, 31, pp. 173–179. doi: 10.1016/j.appdev.2009.12.001.

  274. Quadt, L., Csecs, J., Bond, R. et al. (2024) ‘Childhood neurodivergent traits, inflammation and chronic disabling fatigue in adolescence: a longitudinal case-control study’, BMJ Open, 14(7), e084203. doi: 10.1136/bmjopen-2024-084203.

  275. National Geographic (no date) ‘Why women are the new face of ADHD’. Available at:https://www.nationalgeographic.com/health/article/women-adhd-hyperactivity-diagnoses#:~:text=This%20suggests%20that%20ADHD%20prevalence,re%20a%20pain%20to%20themselves.%E2%80%9D

  276. National Institute for Health and Care Excellence (NICE) (2025) ‘Attention deficit hyperactivity disorder: how common is it?’, February. Available at:https://cks.nice.org.uk/topics/attention-deficit-hyperactivity-disorder/background-information/prevalence/

  277. Guy-Evans, O. (2025) ‘What is a highly sensitive person?’, Simply Psychology, updated August 2025. Originally published March 2022. Available at:https://www.simplypsychology.org/highly-sensitive-persons-traits.html

  278. Broehl, A.S. et al. (2021) ‘Personality profile of the self-identified highly sensitive person: a lay theory approach’, Vol. 43. Available at:https://lirias.kuleuven.be/3651254?&lang=en

  279. Meckovsky, F., Novak, L., Meier, Z. et al. (2025) ‘Highly sensitive persons feel more emotionally lonely than the general population’, Scientific Reports, 15, 2707. doi: 10.1038/s41598-025-87138-w.

  280. Apigian, A. (2025) The Biology of Trauma: How the Body Holds Fear, Pain, and Overwhelm, and How to Heal It. BenBella Books.